Developing a scaffold-based 3D model of neurodegeneration for compound profiling
Important: Prior to applying to this position, please ensure you read through the guidance provided in the ‘how to apply’ section. Applications submitted that do not follow the guidance provided may not be considered.
We are establishing a new state-of-the-art life early science & innovation sciences research facility in London. With a mission of turning breakthrough science into meaningful and impactful medicines, the research focus is in cellular ageing and mechanisms of homeostasis and resilience, the basis of some of the most challenging diseases facing our ageing population.
Who we are…?
We are a global biopharmaceutical leader with a diverse portfolio of prescription medicines, oncology, vaccines and animal health products. We are driven by our purpose to develop and deliver innovative products that save and improve lives. With over 70,000 employees operating in more than 140 countries, we offer state of the art laboratories, plants and offices that are designed to Inspire our employees as we learn, develop and grow in our careers. We are proud of over 125 years of service to humanity and continue to be one of the world’s biggest investors in Research & Development.
We are officially certified by the Top Employer Institute and been awarded the exclusive Top Employer United Kingdom Certification for the third year running.
We are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we “follow the science” and that great medicines can make a significant impact to our world. And we believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe.
Be a part of the legacy: Postdoctoral Research Fellow Program.
Our Research Laboratories’ Postdoctoral Research Fellow Program aims to be a best-in-industry program for industrial postdoctoral researchers, designed to provide you with an academic focus in a commercial environment. With the resources, reach, and expertise of a large pharmaceutical company, postdoctoral researchers will be positioned to excel in an institution committed to breakthrough innovation in research and discovery.
MSD’s London Discovery Centre is seeking a passionate and driven postdoctoral fellow with expertise in neurodegeneration and complex cell cultures to join our biology group for a 3-year postdoctoral fellowship. The focus of the group is investigating age-related neurodegeneration with an emphasis on four key areas; oxidative and ER stress, mitochondrial dysfunction, senescence, and neurogenesis.
The project will use the latest bioprinting techniques, in combination with patient-derived cells and neurocytology expertise to establish a 3D cell culture system that models ageing and/or neurodegeneration, that will be reproducible and reliable for compound profiling. There is a need for more relevant in vitro systems for drug screening, which replicate more closely human physiology in disease. This would strengthen preclinical drug discovery research with the potential to improve translational success rates, which would ultimately have an impact on patients around the world.
The postdoctoral fellow will benefit from access to state-of-the-art equipment, including bioprinters, high-content imagers and multielectrode array systems. They will collaborate and interact with scientists across groups within MSD, who have extensive experience in 3D printing, cellular biology, in vitro pharmacology and chemistry.
Responsibilities include but are not limited to:
- Deliver high quality, reproducible experimental data, which is hypothesis driven
- Design and implement novel disease-relevant cell culture systems
- Understand mechanisms of action using relevant assays
- Differentiate human iPSCs for complex cell culture
- Collaborate with colleagues across MSD to establish a reliable model
- Keep up-to-date with literature in the field and prepare manuscripts
- Contribute to laboratory running tasks and be a conscientious member of the team
- Timely write-up of reports and data
- Regular presentations at internal meetings and at external meetings if the opportunity arises
Education Minimum Requirements:
- Candidates must currently hold a Ph.D. or are expected to complete their Ph.D. by September 2021.
Required Experience and Skills:
- Extensive cell culture experience, including co-culture work
- Expertise in aging and/or neurodegeneration
- Microscopy and cellular imaging experience
- Demonstrated expertise across a broad range of cellular and molecular biology techniques
- Excellent written and oral communication skills
- Excellent attention to detail in experimental design and data analysis.
Preferred Experience and Skills:
- iPSC cell culture and differentiation pathway experience
- Understanding of extracellular matrix properties and/or hydrogels for neuroscience research
- Demonstrated knowledge of drug discovery and assay development,
- Expertise in one of the four areas of London discovery research.
Summer or Autumn 2021
Length of Programme
How to apply:
Please complete the online application form and attach a CV and cover letter.
Please note, that there is not a designated section in the application form to upload your cover letter, so please upload it in the same section as your CV (we recommend submitting your CV and Cover Letter as one combined document).
In your CV, please ensure you include the following information:
- The date (expected or already achieved) of you receiving your Ph.D.
- Details of 2 referees (minimum)
- List of publications (can include posters and talks)
In your Cover Letter, we would encourage you to cover the following:
- How does your expertise match this position?
- What are your research interests and goals?
Additionally, you may include any additional information you feel further supports your application.
Maximum word count for your cover letter: 500 – 600 words. Please do not exceed this.
Other important information:
Our presence in the UK goes back a long way. For over 80 years, we’ve been researching, developing and supplying new medicines and vaccines that prevent and treat diseases that occur at every stage of life.
Today we're one of the top five biopharmaceutical companies in the UK and employ over 2,000 people across five sites in Hertfordshire, Northumberland, Buckinghamshire, Edinburgh and London.
How are MSD in the UK adjusting our hiring process with COVID-19?
At MSD in the UK our key priorities during the current COVID-19 outbreak are both maintaining supply of critical medicines to our patients and ensuring the health and safety of our employees and candidates. In support of Government measures to limit the spread of infection, we have therefore developed a new flexible, virtual route for candidates applying and interviewing for our open roles.
We are proud to be a company that embraces the value of bringing diverse, talented, and committed people together. The fastest way to breakthrough innovation is when diverse ideas come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively. We are an equal opportunity employer, committed to fostering an inclusive and diverse workplace.
What we look for …
In a world of rapid innovation, we seek brave Inventors who want to make an Impact in all aspects of our business, enabling breakthroughs that will affect generations to come. We encourage you to bring your disruptive thinking, collaborative spirit and diverse perspective to our organization. Together we will continue Inventing For Life, Impacting Lives while Inspiring Your Career Growth.
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